A. Kermani , N. Elabbasi 
 Veryst Engineering, Needham, MA, USA
Transdermal drug delivery (TDD) is used to deliver drugs through the skin as an alternative to oral, intravascular, and subcutaneous routes. While there are many advantages to TDD, skin is a very effective barrier and provides resistance to drug delivery. To improve drug delivery through the skin, permeation enhancers are used. We developed an axisymmetric COMSOL Multiphysics® software model ...
S. Curcio and M. Aversa
Department of Engineering Modeling, University of Calabria, Arcavacata di Rende, CS, Italy
The aim of the present work is the formulation of a theoretical model describing the transport phenomena involved in food drying process. The attention has been focused on the simultaneous transfer of momentum, heat and mass occurring in a convective drier where hot dry air flows, in turbulent conditions, around the food sample. The proposed model does not rely on the specification of ...
P. Geraldini ,
 Sogin S. p. A., Rome, Italy
Understanding the air flow patterns and aerosol trajectories in ventilated rooms can provide key information for determining where to place early warning and monitoring instruments, and how to minimize hazardous materials in the worker’s breathing zone. The dispersion within rooms can be influenced by complex interactions between numerous variables, but especially ventilation design and room ...
R. Kher , C. Gallaschun , D. Crockill , R. Pillai , ,
 Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA
Air supply hoses are also predominantly used in the medical industry to aid in patient oxygen intake. In many situations, the outside of the hose can be contaminated with chemicals, especially if the hose lies on the ground in an environment where chemicals are easily found. Permeation and transport of chemicals into the walls of air supply hoses is a noteworthy problem in the chemical ...
P. Le Bideau , R. Cutté , P. Glouannec , J. F. Le Page 
 Univ. Bretagne Sud, FRE CNRS 3744, IRDL, F-56100 Lorient, France
 DPP, ADRIA Développement, Quimper, France
A transient two-dimensional axisymmetric model is implemented in COMSOL Multiphysics® software to simulate temperatures, moisture contents distributions and cake swelling during the baking of cake contained in mold. The medium is assumed to be a deformable porous medium containing three phases: solid (dough), liquid (water) and gas. Gas phase includes two species, water and carbon dioxide. The ...
V. Runkana, A. Pareek, P. Arora
Tata Consultancy Services, Pune, Maharashtra, India
Indian Institute of Technology Delhi, New Delhi, Delhi, India
Limited drug efficacy, undesirable temporal changes in drug concentration and patient non-compliance due to frequent dosing schedule have given impetus to design of controlled drug release systems . Biodegradable polymers due to their favorable and tunable properties and biocompatibility have found widespread use in the field of controlled drug delivery . Exploratory in vitro experiments ...
P. L. Mills , M. Vasilev , P. Sharma ,
 Department of Chemical and Natural Gas Engineering, Texas A&M University - Kingsville, Kingsville, TX, USA
Introduction Use of simulation software for solving realistic engineering problems has grown significantly in recent years due to the availability of less expensive but more powerful computers and development of user-friendly yet robust codes. From an educational perspective, students in STEM disciplines can now solve complex problems in a relatively short period of time, which provides new ...
S. Pramanik, M. Mishra
Indian Institute of Technology Ropar, Rupnagar, Punjab, India
Viscous fingering (VF) instability has been extensively studied over past several decades in the context of various industrial, environmental and chemical processes. We try to model miscible VF at pushed or pulled interfaces using COMSOL Multiphysics®. We study the effect of the positive and negative log-mobility ratio on the fingering instability. Numerical simulation has been performed in 2D ...
I. Neitzel, R. C. F. do Nascimento, C. C. Bueno
Faculdade de Telêmaco Borba - FATEB, Telêmaco Borba, Paraná, Brasil
Neste trabalho é analisado o comportamento dos perfis de temperatura e umidade e sua penetração em bobinas de papel submetidas a longos períodos de armazenagem. O modelo considera a transferência simultânea de calor e massa com o efeito Soret, mas sem o efeito Latour. O sistema é fechado em relação à umidade e aberto em relação à energia. As propriedades térmicas são dependentes da umidade e ...
Theoretical and Practical Approach for Transdermal Drug Delivery using Microneedle for Successful Skin Penetration
Jeevan J.Mahakud, Ziaur Reheman
Department of electronics and Communication engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
Department of electronics and instrumentation engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
With the advent of MEMS, transdermal drug delivery has been developed to increase skin permeability for drug transport. Various microneedle structures have been analyzed theoretically as well as through simulation using COMSOL Multiphysics®. Then computational fluid dynamics has been presented in order to study the behavior of the fluid flow inside the microneedle cavity. In this report, the ...