Presentazioni e Articoli Tecnici

In questa sezione troverete i lavori presentati alle Conferenze mondiali COMSOL. Le presentazioni descrivono ricerche e prodotti innovativi progettati con COMSOL Multiphysics da colleghi di tutto il mondo. I temi delle ricerche presentate abbracciano un'ampia gamma di settori produttivi e aree applicative, in ambito elettrico, meccanico, fluidodinamico e chimico. Lo strumento di Ricerca Rapida vi permetterà di trovare le presentazioni che si riferiscono all'area di vostro interesse.

Investigation Of Bone Marrow Stem Cells In The Bone Marrow Niche In An In Vitro System

P. Lezuo, M. Stoddart, and M. Alini
AO Research Institute, Davos, Grison, Switzerland

We aim to develop an in vitro culture system to mimic the human bone marrow stem cell niche in an artificial perfusion bioreactor environment to culture human adult stem cells. State of the art human bone marrow stem cell research shows that even smallest changes in the physical, thermo dynamical or biochemical environment induce a differentiation of human bone marrow stem cells into other cell ...

The Effects of the Electrical Double Layer on Giant Ionic Currents through Single Walled Carbon Nanotubes

G. Zhang[1][,][2][,][3], S.L. Bearden [1]
[1]Department of Bioengineering, Clemson University, Clemson, SC, USA
[2]Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA
[3]Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC, USA

Electrofluidic transport through a single walled carbon nanotube (SWCNT) is enhanced by electroosmosis. Electroosmosis is made possible in these devices by the combination of a large slip length within SWCNTs and the interfacial potential at the solution/nanotube interface. A computational model of a SWCNT device was developed using COMSOL Multiphysics to investigate the complete electrical ...

3D-FEA of the Relationship between the Occiput and Sphenoid in the Osteopathic Paradigm - new

Y. Chiesa[1]
[1]Istituto Superiore di Osteopatia, Milan, Italy

The concept of cranial Primary Respiratory Mechanism (MRP) is used by osteopathic practitioners to explain the perceptual characteristics arising from the clinical palpation approach of the human skull. The theoretical apparatus and the same MRP existence is always element of controversy among the scientific community. The results arising from this study highlight the intrinsic capability of the ...

Modeling and Simulation of Drug Release through Polymer Matrices - new

V. Runkana[1], A. Pareek[1], P. Arora[2]
[1]Tata Consultancy Services, Pune, Maharashtra, India
[2]Indian Institute of Technology Delhi, New Delhi, Delhi, India

Limited drug efficacy, undesirable temporal changes in drug concentration and patient non-compliance due to frequent dosing schedule have given impetus to design of controlled drug release systems [1]. Biodegradable polymers due to their favorable and tunable properties and biocompatibility have found widespread use in the field of controlled drug delivery [2]. Exploratory in vitro experiments ...

Local Electroporation of Single Adherent Cells by Micro-Structured Needle Electrodes

K. K. Sriperumbudur[1], P. J. Koester[1], M. Stubbe[1], C. Tautorat[1], J. Held[2], W. Baumann[1], and J. Gimsa[1]
[1] University of Rostock, Chair of Biophysics, Gertrudenstr. 11a, 18057 Rostock, Germany
[2] Microsystem Material Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany

In spite of its low throughput, Patch-Clamp is the established method for intracellular measurements of the transmembrane potential. To address this problem, we have developed new biosensor-chips with micro-structured needle electrodes (MNEs). MNE-penetration of single cells growing on the MNE-tips leads to a situation comparable to the whole-cell mode in classical Patch Clamp. MNE-penetration ...

Bending of a Stented Atherosclerotic Artery

H.C. Wong[1], K.N. Cho[1], and W.C. Tang[1]

[1]Department of Biomedical Engineering, University of California, Irvine, California, USA

Atherosclerosis causes the deposition of plaque on the inner walls of arteries, which leads to restricted blood flow. Using the balloon angioplasty procedure, stents can be inserted and expanded in the atherosclerotic artery. We used COMSOL Multiphysics Structural Mechanics, Solid Stress-Strain module to perform static, large deformation analyses. Our results show that lower stent stresses were ...

Fluid Dynamics of Blood Flow during Reperfusion and Post-conditioning

T. Merrill[1], A. La Barck[1], and J. Docimo[2]
[1]Rowan University, Glassboro, New Jersey, USA
[2]FocalCool, LLC, Mullica Hill, New Jersey, USA

Reperfusion injury is caused by the rapid restoration of blood flow to oxygen-starved tissue. Animal studies show that intermittent periods of occlusion (also called post-conditioning) during reperfusion can limit tissue damage to vital organs such as the heart and brain. These studies suggest that the protective effects of post-conditioning relate to the dynamics of blood flow. COMSOL is being ...

Designing an Array of Nanocalorimeters for Screening Biochemical Interactions

F. Torres
Palo Alto Research Center

In this presentation we present our analysis of the PARC Nanocalorimeter. Calorimetry is basically the measuring of heat of chemical reactions or physical changes. Nanocalorimetry is Calorimetry at the Nanometer scale. The PARC Nanocalorimeter is a special type of Calorimeter, it consists of arrays of Nanocalorimeters. The PARC Nanocalorimeter is intended to be used for screening biochemical ...

Detection of E.coli Cell using Capacitance Modulation

A.K. Dwivedi, R.M. Patrikar, R.B. Deshmukh, and G. Pendharkar
Visvesvaraya National Institute of Technology, Nagpur, Maharashtra, India

Testing and verification is very important to increase reliability of a system. In water analysis its purity is verified using different test methods. Biosensors are very useful to detect the microorganisms present in water. This paper presents a method to detect E.coli bacteria in water depending upon the capacitance modulation in the presence and absence of E.coli cell, which is simulated in ...

Physical and FEM Simulation of Microprobe Insertion into Brain Tissue

A. Eed Olamat, U. Hofmann, B. Pohl, and N. Nkemasong
University of Lübeck, Institute for Signal Processing, Lübeck, Germany

In order to investigate the implantation of microprobes into brain tissue, we developed a finite-element and a physical model to replace real biological tissue for mechanical testing. Penetrating forces of a tungsten indenter into a layered structure was investigated with different indentation speeds. Numerical and physical model are in good correspondence to each other and reproduce measured ...

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