In questa sezione troverete i lavori presentati alle Conferenze mondiali COMSOL. Le presentazioni descrivono ricerche e prodotti innovativi progettati con COMSOL Multiphysics da colleghi di tutto il mondo. I temi delle ricerche presentate abbracciano un'ampia gamma di settori produttivi e aree applicative, in ambito elettrico, meccanico, fluidodinamico e chimico. Lo strumento di Ricerca Rapida vi permetterà di trovare le presentazioni che si riferiscono all'area di vostro interesse.

Thermal-Optical Modeling of a Signal Enhancement Approach for Paper-Based Diagnostics

D. Gasperino [1]
[1] Intellectual Ventures Laboratory, Bellevue, WA, USA

INTRODUCTION: Point of care diagnostics aimed at low-resource settings need to be relatively simple, robust and low-cost. The most commonly-used diagnostic platform in these settings is the lateral flow assay (LFA). LFAs are paper-based immunoassays designed to perform on-strip binding with analytes in patient samples in order to generate a visual signal if disease-specific antigen is ...

Modelling of Thermally Induced Electrical Instabilities in Intestine using COMSOL Multiphysics®

A. Gizzi[1][3], C. Cherubini[1][2], S. Migliori[1][3], and S. Filippi[1][2]
[1]Nonlinear Physics and Mathematical Modeling Lab, Engineering Faculty, University Campus Bio-Medico, Roma, Italy
[2]International Center for Relativistic Astrophysics, University of Rome La Sapienza, Roma, Italy
[3]Alberto Sordi Foundation, Research Institute on Aging, Roma, Italy

Postoperative or paralytic Ileus (PI) is a temporary aftermath of major abdominal surgeries. PI prevents the passage of food throughout the lumen leading to bloating, distension, emesis and pain. A plausible mathematical model for this phenomenology physiologically fine tuned including thermal variations, is presented here. Using COMSOL Multiphysics the existing intestinal ionic model have been ...

Inlay Fixed Partial Denture Framework 3-D Structural Integrity Validation Using COMSOL Multiphysics®

T.M.R. Alho[1]

[1]Department of Electrical Engineering and Automation, University of Vaasa, Vaasa, Finland

Manual manufacturing of inlay fixed partial denture frameworks by metal casting can take hours of dental practitioners work time. This paper introduces 3-D simulations of premanufactured inlay fixed partial denture framework assembled from laser cut sheet metal parts. The study gives a good estimation of how well the frameworks can withstand strong human occlusion forces and masticatory cycle. ...

Coupled Fluid-Structural Analysis of Heart Mitral Valve

A. Avanzini, and G. Donzella
Department of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy

The mitral valve apparatus is a complex and refined mechanism located between the left atrium and the left ventricle of the heart which can manifest various kinds of pathologies. In order to support identification of potentially critical conditions resulting from some typical cardiosurgery operations, it is important to develop models of the mitral valve that enable prediction of both stress in ...

Computer Simulation Of Haematopoietic Stem Cells Migration Using COMSOL Multiphysics

G. Bencheva
Institute for information and communication technologies, Bulgarian Academy of Sciences, Sofia, Bulgaria

Various haematological diseases, including leukaemia, are characterized by abnormal production of particular blood cells. Two important properties of haematopoietic stem cells (HSCs) are used in their therapy, namely: a) rapid migratory activity and ability to \'\'home\'\' to their niche in the bone marrow; b) high self-renewal and differentiation capacity, responsible for the production and ...

Analyzing Drug Delivery and Osteoblast Growth on a Porous Scaffold in a Perfusion Bioreactor

A. Sun, and S. Murray
Dept. of Biomedical Engineering
UCLA, Los Angeles, CA

Implantable Collagen sponges are used in Spinal Surgery as Drug Delivery Scaffolds. An optimal concentration of growth factor that strikes a balance between bone growth and adverse diffusion effects is difficult to find. The porous sponge also serves as a scaffold for Osteoblast growth, and fluid shear has been shown to mediate biological effects on that cell type. We use COMSOL Multiphysics ...

COMSOL Multiphysics® Model of Canine Elbow for Use in Investigating Medial Coronoid Disease

K. A. Bodnyk[1], G. J. Noble[1], N. Fitzpatrick[2], M. J. Allen[3], K. Stephenoff[1], R. T. Hart[1]
[1]Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA
[2]Fitzpatrick Referrals, Godalming, Surrey, United Kingdom
[3]Department of Veterinary Medicine, The Ohio State University, Columbus, OH, USA

The elbow joint in dogs constitutes a complex interaction of three bones, the humerus, radius and ulna. Medial coronoid disease (MCD) is a common cause of lameness in dogs, i.e. fracturing of the most prominent portion of the ulnar joint surface driven in flexion and in pivot against both the humerus and the radius. The cause remains unknown, but prior studies suggest joint incongruency as an ...

Can Oscillatory Convection Accelerate Signal Propagation in Simple Epithelium?

M. Nebyla[1], M. Pribyl[1]
[1]Institute of Chemical Technology, Prague, Department of Chemical Engineering, Prague, Czech Republic

We introduce a mathematical model of signal transmission in simple epithelial layers. The mathematical model consists of reaction-transport equations for extracellular ligands, cellular receptors, ligand-receptor complexes and a ligand releasing protease. We consider diffusion and nonstationary convective transport of protein ligands in the extracellular space. The study was carried out using ...

Extending Engineering Simulations to Scientists: Food Safety and Quality Prediction Using COMSOL Multiphysics® and LiveLink™ for Excel®

A. Warning[1], A. K. Datta[1]
[1]Cornell University, Ithaca, NY, USA

The objective of this study was to develop an easy to use interface in Excel® that connects to not only the solvers in COMSOL Multiphysics®, but also existing databases of food properties, foodborne pathogenic microorganisms kinetics, and chemical kinetics, creating a comprehensive simulation software to predict food safety and quality. The user interface allows the user to select the food, ...

Simulation of Convection in Water Phantom Induced by Periodic Radiation Heating

H.H. Chen-Mayer[1], and R. Tosh[1]
[1]Ionizing Radiation Division, National Institute of Standards and Technology, Gaithersburg, Maryland, USA

Water calorimetry is employed to establish a primary reference standard for radiation dosimetry by measuring the temperature rises in a water phantom (a cube of about 30 cm x 30 cm x 30 cm) subjected to a beam of ionizing radiation.  We use COMSOL Multiphysics to model the system using the Heat Transfer module and the Incompressible Navier-Stokes module with a geometry of 2D-axial ...