P. Wijdenes , H. Ali , N. Syed , C. Dalton ,
 Centre for Bioengineering Research and Education, University of Calgary, Calgary, AB, Canada
 Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
 Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada
Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our capabilities to perform long-term recordings, this has been at the expense of signal resolution due to low sealing ...
R. Penjweini , T. C. Zhu , M. M. Kim ,
 Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Photofrin-mediated photodynamic therapy (PDT) is used after surgical resection at the University of Pennsylvania to treat the microscopic disease for malignant pleural mesothelioma and to increase survival rate. When Photofrin is exposed to laser light at 630 nm in well-oxygenated tissue, it produces reacted singlet oxygen ([1O2]rx) that kills cancer cells. As [1O2]rx is imperative to PDT ...
J. S. Crompton , J. Thomas , K. Koppenhoefer ,
 AltaSim Technologies, Columbus, OH, USA
Necrosis of human tissue can typically be obtained by exposure to temperatures below 40°C or above +50°C. However, inherent variability in tissue properties, the complexity of tissue response and dissipation of thermal energy by local perfusion or blood flow can make the development of routine, predictable in-vivo approaches to produce necrosis difficult. Although a number of thermal ablation ...
Passive and Active Deformation Processes of 3D Fibre-Reinforced Caricatures of Cardiovascular Tissues
A. Di Carlo, P. Nardinocchi, T. Svaton, and L. Teresi
Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
Dept. of Structural & Geotechnical Engineering, Università di Roma La Sapienza, Roma, Italy
Dept. of Mathematics, University of West Bohemia, Pilsen, Czech Republic
In this paper, we present a mathematical model of contractile elastic solids meant to simulate various districts of the cardiovascular system, and based on the concepts of active deformation and embedded muscle fibres. Specifically, here we deal with the modeling of the gross mechanics of the Left Ventricle (LV) which is strictly related to its pump function. As is well known, the effectiveness ...
Y. Song, and C. Wang
Florida International University, Miami, FL, USA
Enzymatic biofuel cells (EBFCs) are miniature, implantable power sources, which use enzymes as catalysts to perform redox reaction with biological fuels such as glucose. In this study using COMSOL Multiphysics, we use an EBFC chip, having three dimensional, highly dense micro-electrode arrays, fabricated by C-MEMS micro-fabrication techniques. Glucose oxidase (GOx) is immobilized on anodes for ...
G. Zhang, Y. Zhao, J. Brcka, J. Faguet, E. Lee
Clemson University, Clemson, SC, USA
TEL U.S. Holdings, Inc., U.S. Technology Development Center, Austin, TX, USA
In our experiments with manipulating cells with DEP, we noted that some cells are constantly spining. By hypothesing that the cell spining is caused by the non-circular shape of the cell body and the off-centered location of its nucleus and that the rotation direction depends on the relative location of nucleus with respect to the electrical field, we found that the observed cell rotation was ...
K. Cluff, H. Mehraein, B. Jayakumar
Department of Bioengineering, Wichita State University, Wichita, KS, USA
Department of Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA
Background: Peripheral arterial disease (PAD) is characterized by atherosclerotic blockages of the arteries supplying the lower extremities, which cause a progressive accumulation of ischemic injury to the skeletal muscles of the lower limbs. Despite revascularization treatment intervention some PAD patients require follow up secondary treatment due to a continued decline in limb function, ...
Temperature Excursions at the Pulp-Dentin Junction during the Curing of Light-Activated Dental Restorations
M. Jakubinek[1,2], C. Neill, C. Felix, R. Price[2,3], M. White[1,2]
Departments of Chemistry and Physics, Dalhousie University, Halifax, NS, Canada
Institute for Research in Materials, Dalhousie University, Halifax, NS, Canada
Department of Dental Clinical Sciences, Dalhousie University, Halifax, NS, Canada
Heat produced during the curing of light-activated dental restorations could damage the dental pulp. Given the prevalence of composite restorations and the importance of avoiding injury to the pulp, efforts should be made to minimize the temperature increase that occurs at the pulp-dentin junction during light-curing. In this investigation we develop and evaluate a COMSOL Multiphysics FEM tooth ...
K. K. Sriperumbudur, P. J. Koester, M. Stubbe, C. Tautorat, J. Held, W. Baumann, and J. Gimsa
 University of Rostock, Chair of Biophysics, Gertrudenstr. 11a, 18057 Rostock, Germany
 Microsystem Material Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany
In spite of its low throughput, Patch-Clamp is the established method for intracellular measurements of the transmembrane potential. To address this problem, we have developed new biosensor-chips with micro-structured needle electrodes (MNEs). MNE-penetration of single cells growing on the MNE-tips leads to a situation comparable to the whole-cell mode in classical Patch Clamp. MNE-penetration ...
Computational Modeling of the Electrohydrodynamics Influencing Trace Mercury Adsorption within Electric Utility Electrostatic Precipitators
University of Michigan, Ann Arbor, MI, USA
Anthropogenic mercury (Hg) emissions increase the risk of neurological and neonatal health effects in humans through fish consumption. There are several technological approaches to controlling mercury emissions from coal combustion, including the injection of a powdered mercury sorbent into the flue gas upstream of the particulate control device (PCD). As most PCDs are electrostatic ...