In questa sezione troverete i lavori presentati alle Conferenze mondiali COMSOL. Le presentazioni descrivono ricerche e prodotti innovativi progettati con COMSOL Multiphysics da colleghi di tutto il mondo. I temi delle ricerche presentate abbracciano un'ampia gamma di settori produttivi e aree applicative, in ambito elettrico, meccanico, fluidodinamico e chimico. Lo strumento di Ricerca Rapida vi permetterà di trovare le presentazioni che si riferiscono all'area di vostro interesse.

Simulation of Normal and Cancerous T-cell Membrane Electroporation - new

O. Henao[1], V. Gómez[1], I. De la Pava[1], J. Sánchez[1]
[1]Grupo Fisiología Celular y Aplicada, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia

Electroporation is an increase of the cell membrane permeability due to the formation of aqueous pores in it when the cell is under the influence of an intense electric field [1][2]. The formation of such pores in the membrane can be used to enhance the uptake of chemotherapeutic drugs into the cell in a cancer treatment known as electrochemotherapy [3]. In some cases the direct experimental ...

Computational Design and Optimization of Bone Tissue Engineering Scaffold Topology

N. P. Uth [1], J. Mueller [2], B. Smucker [3], A. Yousefi [1],
[1] Department of Chemical, Paper, and Biomedical Engineering, Miami University, Oxford, OH, USA
[2] Research Computing Support, Miami University, Oxford, OH, USA
[3] Department of Statistics, Miami University, Oxford, OH, USA

Introduction: Bone tissue has a limited ability for regeneration; critically sized defects cannot self-heal and require medical intervention. Bone tissue engineering (TE) circumvents this issue by growing replacement bone tissue from the patient’s own cells inside scaffolds. TE scaffolds are porous constructs that act as a support structure during bone regeneration and helps cells attach and ...

Multiphysics Modeling of Cellular Arrays Using Periodic Minimal Surfaces – A Drug and Gene Delivery Application

J.I. Rey, A.J. Llewellyn, R.J. Connolly, J.P. Jimenez, A.M. Hoff, and R.A. Gilbert
University of South Florida, Tampa, FL, USA

Minimal surfaces are found in nature from crystalline structures to biological nano and micro structures such as biomembranes, and osseous formations in sea urchin. An application to electrically mediated drug and gene delivery is presented. Periodic level surfaces which approximate minimal surfaces are used to generate a geometric representation of tissue. A method to create such structures ...

Bone Remodeling Following Total Hip Replacement: Short Stem Versus Long Stem Implants

M.S. Yeoman[1], A. Cizinauskas[1], C. Lowry[2], G. Vincent[3], S. Collins[3], D. Simpson[3]
[1]Continuum Blue, Tredomen, Ystrad Mynach, United Kingdom
[2]Corin Group, Cirencester, United Kingdom
[3]Imoprhics, Manchester, United Kingdom

Bone resorption around hip stems, in particular periprosthetic bone loss, is a common observation post-operatively. A number of factors influence the amount of bone loss over time and the mechanical environment following total hip replacement (THR) is important. Conventional long stem prostheses have been shown to transfer loads distally, resulting in bone loss of the proximal femur. More ...

Computationally Assisted Design and Experimental Validation of a Novel ‘Flow-Focussed’ Microfluidics Chip for Generating Monodisperse Microbubbles

M. Conneely[1], V. Hegde[2], H. Rolfsnes[1], A. Mason[2], D. McLean[1], C. Main[1], F.J.D. Smith[2], W.H.I. McLean[2], P.A. Campbell[1]
[1]Carnegie Physics Laboratory, University of Dundee, Dundee, Scotland, United Kingdom
[2]Division of Molecular Medicine, University of Dundee, Dundee, Scotland, United Kingdom

Whilst initially developed as a diagnostic aid to improve echogenicity in ultrasound imaging, gas-filled lipid microbubbles are now emerging as a next generation \'theranostic\' tool in the medical arena. Here, their therapeutic potential has now been realized through their unique capability to deliver molecular species such as drugs and genes by means of disrupting the cell membrane in response ...

Three-Dimensional Finite Element Modeling of Current Density in Maternal Transthoracic Defibrillation

A. Jeremic[1], J. Potts[2], E. Khosrowshahli[1]
[1]McMaster University, Hamilton, ON, Canada
[2]McMaster University Hospital, Hamilton, ON, Canada

Although the cardiac arrest in pregnancy is a rare event it can have significant impact in terms of age of mother, mortality of unborn children and consequently long-term effect. One of the commonly used procedures in resuscitation is defibrillation. With recent advances in understanding pathophysiologies in pregnant women it became more obvious that previous studies should be extended to ...

Lowering of the Interstitial Fluid Pressure as a Result of Tissue Compliance Changes during High Intensity Focused Ultrasound Exposure: Insights from a Numerical Model

E. Sassaroli[1], B. O'Neill [1]
[1]The Methodist Hospital Research Institute, Houston, TX, USA

Interstitial fluid pressure (IFP) is elevated in tumors. Owing to this elevated IFP, the interstitial fluid velocity (IFV) is negligible throughout the tumor but significant near the tumor margin. Any therapeutic strategy that can lower IFP will improve drug convection within the tumor and decrease convection of drugs from the tumor margin. High intensity focused ultrasound (HIFU) has been shown ...

Modeling Interface Response in Cellular Adhesion

G. Megali[1], D. Pellicanò[1], M. Cacciola[1], F. Calarco[1], D. De Carlo[1], F. Laganà[1], and F.C. Morabito[1]

[1]DIMET Department, Faculty of Engineering, University “Mediterranea” of Reggio Calabria, Reggio Calabria, Italy

Constitutive properties of living cells are able to withstand physiological environment as well as mechanical stimuli occurring within and outside the body. We examined fluid flow and Neo-Hookean deformation related to the rolling effect. A mechanical model to describe the cellular adhesion with detachment is here proposed. We developed a finite element analysis, simulating blood cells attached ...

Drug Distribution in the Human Eye

L. Murtomäki[1], T. Kainuvaara[1]
[1]University of Helsinki, Helsinki, Finland

Drug therapy of the posterior segment of an eye is very challenging due to the difficult accessibility. Modern drugs often are large molecules, such as peptides, antibodies or oligonucleotides which are administrated, e.g. by intravitreous injections which requires clinical conditions. Computer modeling can be helpful in designing new and less invasive routes of drug administration. COMSOL is ...

A Mathematical Tool for Studying Drug Delivery to the Eye in Case of Glaucoma

P. Silva[1], J.A. Ferreira[2], P. de Oliveira[2]
[1]Coimbra Institute of Engineering, CMUC, Coimbra, Portugal
[2]Department of Mathematics University of Coimbra, CMUC, Coimbra, Portugal

The aim of the poster is to present a coupled 2D mathematical model to predict the evolution of drug concentration - in the cornea and in the anterior chamber of the eye - when therapeutic lenses are used (Figure 1). The mathematical model takes into account (i) diffusion processes in several compartments of the eye (therapeutic lens, cornea and anterior chamber); (ii) metabolic consuming ...