Polymer Compositional Profile Controls By-Product Fate from Erodible Endovascular Scaffolds

T. Shazly, and J. Ferdous
Biomedical Eng., Mechanical Eng. Dept.
University of South Carolina
Columbia, SC
Published in 2011

Erodible polymeric scaffolds can mitigate long-term risks associated with permanent implants currently used to treat ischemic artery disease. However, safe deployment of erodible scaffolds is predicated on understanding the interactions between evolved material by-products and local biological tissues.

We developed an integrated computational model of polymeric scaffold degradation, by-product transport, and metabolism to study how the initial molecular weight distribution (MWD) of polylactic acid (PLA) influences by-product fate in the arterial environment. A series of parametric studies were conducted to determine how initial scaffold MWD and carboxylic acid content impact polymer degradation kinetics and transient by-product tissue concentrations throughout the erosion process.