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Modeling large surface deformation in cryopreservation by vitrification

David G, CMU

The behavior of the cryoprotective agents changes from liquid to solid during vitrification. In this model, I solved the coupled problem of heat transfer and fluid flow problem during cryopreservation, while considering surface tension. The results are in good agreement with the cryomacroscopy experiments.

This is a multi-physics model I developed in a small project in October 2019 to model large surface deformation and residual stresses during cryopreservation by vitrification.
To learn about cryopreservation: Bojic et al. Winter is coming: the future of cryopreservation. BMC Biol 19, 56 (2021).
To cite my model:
Guirguis, Rabin, "Modeling surface deformation in large-scale cryopreservation by vitrification," Cryobiology, 97 (264), December 2020. DOI: 10.1016/j.cryobiol.2020.10.064

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