Simulation of Chemotractant Gradients in Microfluidic Channels to Study Cell Migration Mechanism in Silico
P. Wallin, E. Bernson, J. Gold
Chalmers University of Technology, Applied Physics, Biological Physics, Gothenburg, Sweden
Cell migration of endothelial cells along gradients is an important process in vivo and an interesting target for cancer therapeutics. Microfluidics offer very powerful tools to study such migration processes in detail in the lab. In this study, we describe a model to simulate molecular gradients in a diffusion based microfluidic gradient generator and how a cell senses these gradients via cell ...
A Multiphase Porous Medium Transport Model with Distributed Sublimation Front to Simulate Vacuum Freeze Drying
A. Warning, J. M. R. Arquiza, A. K. Datta
Cornell University, Ithaca, NY, USA
A continuum, porous medium formulation with non-equilibrium sublimation was developed and validated for freeze drying without and with uniform microwave volumetric heating. The model incorporates the effect of Knudsen flow at low pressure and low permeability freeze drying. The distributed, non-equilibrium sublimation demonstrated that the sublimation front is a sharp boundary for high ice ...
M. K. Gobbert, X. Huang, S. Khuvis, S. Askarian, B. E. Peercy
University of Maryland - Baltimore County, Baltimore, MD, USA
This paper presents information on techniques needed in COMSOL Multiphysics® to enable computational studies of coupled systems of PDEs for time-dependent non-linear problems. Furthermore, we demonstrate how to use data files as input for initial conditions. To illustrate the techniques, we consider a system of two time-dependent non-linear PDEs from mathematical biology that couples an ...
C. Gavrila, A. Ghiaus, and I. Gruia
Technical University of Civil Engineering Bucharest, Faculty of Building Services, Bucharest, Romania
University of Bucharest, Faculty of Physics, Bucharest, Romania
A dynamic mathematical model, based on physical and transport properties and mass and energy balances, was developed for the simulation of unsteady convective drying of agricultural products (fruits and vegetables) in static bed conditions. The model utilizes water sorption isotherm equations and the change in solid density due to the shrinkage phenomenon. The aim of this article is to describe ...
A Practical Method to Model Complex Three-Dimensional Geometries with Non-Uniform Material Properties Using Image-based Design and COMSOL Multiphysics®
J. Cepeda, S. Birla, J. Subbiah, H. Thippareddi
Department of Food Science & Technology, University of Nebraska, Lincoln, NE, USA
Department of Biological Systems Engineering, University of Nebraska, Lincoln, NE, USA
Geometries with heterogeneous material properties are typically defined as a set of multiple parts, each part representing a different material. However, assembling or defining the individual parts of complex geometries can be difficult. A practical method based on image-based mesh generation, a custom algorithm for labeling materials, and interpolation functions of COMSOL Multiphysics® can be ...
J. Soons[1,2], C. Steele, S. Puria
Lab of Biomedical physics, University of Antwerp, Antwerp, Belgium
Department of Mechanical Engineering, Stanford University, Stanford, USA
Sound vibrations are collected from the external environment by the eardrum and are guided to the basilar membrane in the cochlea. Pressure differences in the two scalae of the cochlea result in a traveling wave on the basilar membrane. The tiny displacements are detected by the deflection of thousands of hair cells, situated along this membrane. It is hypothesized that some 3/4 of these hair ...
Acoustic Field Comparison of High Intensity Focused Ultrasound Using Experimental Characterization and Finite Element Simulation
J. L. Teja, A. Vera, L. Leija
Department of Electrical Engineering, Cinvestav-IPN, Mexico D.F., Mexico
High Intensity Focused Ultrasound (HIFU) is used as a noninvasive technique of tissue heating and ablation for different medical treatments. This paper presents a quantitative comparison of HIFU acoustic fields experimentally obtained versus simulated acoustic fields. Acoustic field characterization was realized in two HIFU transducers using water as a propagation medium. Also, simulations were ...
Heat Transfer and Phase Transformation on Matrix Assisted Pulsed Laser Evaporation (MAPLE) of Biocompatible Thin Layers
E. Lacatus, G.C. Alecu, M.A. Sopronyi, A. Tudor
POLITEHNICA University of Bucharest, Bucharest, Romania
INFLPR -National Institute for Laser Plasma and Radiation Physics, Bucharest, Romania
Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique is used for the deposition of high quality biocompatible polymer thin films. During the deposition process the temperature of the laser target should be kept below 193K to assure the proper quality of both evaporation and deposition phases of the process. On a first approach COMSOL Multiphysics® was used to describe and analyze the ...
E. Isaza, E. Salazar, L. Florez
Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia
The consequences of hip fracture and femoral fracture are widely known. The mechanical strength of the femur varies in every person, but it is possible to predict the mechanical resistance with parameters like density, dimensions and mineral content. This paper uses different models and empirical studies to determine the mechanical properties of the human femur, developing isotropic and ...
J.G. Pieters, R. ElGamal, F. Ronsse
Faculty of Bioscience Engineering, Department of Biosystems Engineering, Ghent, Belgium
CFD simulations were carried out to predict the convective heat and mass transfer coefficients in the rice bed, and correlations were developed for the convective heat and mass transfer coefficients as a function of drying air flow rate. The developed correlations were used to extend the model developed by ElGamal et al. (2013) for thin-layer rice drying to volumetric heat and mass transfer in a ...