A. Lucantonio, P. Nardinocchi, L. Teresi
Università degli Studi La Sapienza, Roma, Italy
LaMS - Modelling & Simulation Lab, Università degli Studi Roma Tre, Roma, Italy
Polymer gels belong to the realm of soft active materials as they are capable of responding to a non-mechanical stimulus – the permeation of a solvent – with a mechanical action – a volume change, thanks to the coupling between different physics. This mechanism of coupling can be exploited in a wide range of applications, including biomedical devices, making crucial the understanding of the ...
P. Pattanaik, S. K. Kamilla, D. P. Das, S. K. Pradhan
MEMS Design Center, Institute of Technical Education & Research (ITER), Sikhya ‘O’ Anushandhan University, Bhubaneswar, Odisha, India
Process Engineering and Instrumentation Lab, Institute of Minerals and Materials Technology (IMMT), Bhubaneswar, Odisha, India
Dept of ECE, Hi-Tech Institute of Technology, Khurda, Odisha, India
This paper describes the design of an ultrasonic transducer using different lead free piezo-electric materials and evaluates their performance with different glucose levels in the human blood. COMSOL Multiphysics 4.2a was used for the simulation study using 2D axis symmetric model of piezoelectric transducer which was designed with lead free piezoelectric materials such as Barium Sodium Niobate ...
J. Rasmussen, M.S. Enevoldsen, J. Thyregod, and K-A. Henneberg
Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark
COOK Medical Europe, Bjaeverskov, Denmark
This work presents new Fluid-Structure Interaction (FSI) models in both 2D and 3D of the effect of using vascular stents as treatment of cerebral berry aneurysms. The stent is positioned inside the cerebral artery covering the neck of the aneurysm. The stent is expected to alter the blood flow into the aneurysm such that the blood coagulates due to low blood velocity, and rupture of the aneurysm ...
J. C. Kumaradas, A. Zhang, Y. D. Davletshin
Ryerson University, Toronto, ON, Canada
University of Waterloo, Waterloo, ON, Canada
Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, size, analyte concentration and type to predict the number of nucleic acid molecules captured by ...
Design and Simulation of a Microscale Magnetophoretic Device for the Separation of Nucleated Fetal Red Blood Cells from Maternal Blood
G. Schiavone, D.M. Kavanagh, and M.P.Y Desmulliez
Politecnico di Torino, Torino, Italy
MIcroSystems Engineering Centre, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh, Scotland, United Kingdom
Intense research has been carried out into methods that aim at harvesting fetal cells from maternal blood as substitutes to amniocentesis and chorionic villus sampling. This work focuses on the separation of fetal nucleated red blood cells from the maternal circulation based on their intrinsic magnetic properties. The design and simulation of a magnetophoretic separator is described, as it will ...
P. Krastev, and B. Tracey
Neurometrix, Inc., Waltham, Massachusetts, USA
Nerve localization is important for applications in regional anesthesia. Localization is achieved by stimulating the nerve with an electric field produced by a current from a needle inserted into the body of the patient, close to the target nerve. Modeling of the electric field in close proximity to the nerve may help to explain observed variations in threshold currents and can help to ...
E. P. Furlani, N. M. Litchinitse, and R. Biswas
The Institute for Lasers, Photonics and Biophotonics, University at Buffalo, Buffalo, New York, USA
Department of Electrical Engineering, The State University of New York at Buffalo,Buffalo, New York, USA
We present a study of an optofluidic biosensor. The sensor operates in a transmission mode wherein detection is based on a shift in the transmission spectrum caused by the contrast in refractive index between the carrier fluid and the target biomaterial. We study the behavior of the sensor using 2D full-wave electromagnetic analysis, and perform parametric studies of sensitivity as a function of ...
A. D. Haydock, J. Melrose, P. Rayment, M. F. Butler, and G. Lian
Unilever R&D Colworth, Colworth House, Sharnbrook Bedford, UK
In this presentation, we describe the use of COMSOL for modeling release of active molecules from hydrogels as a model system of structured foods. We first discuss the structural changes of hydrogel in the gastro-intestinal (GI) tract environment and how this is modelled mathematically. We then discuss how to implement the mathematical equations in COMSOL. Computer simulations have been performed ...
3-D Multiphysics FEM Modeling to Optimize Local Drug Delivery in a Biohybrid Device Designed for Cell Transplant
N. Bocca, C. Ricordi, N. S. Kenyon, P. Latta, and P. Buchwald
Diabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA
To evaluate the possibility of achieving drug concentration levels required for localized immunosuppression and to optimize sustained, local delivery within small, subcutaneously implanted, prevascularized biohybrid devices designed to achieve long-term survival of transplanted pancreatic islets, finite element method (FEM)-based models have been implemented in COMSOL Multiphysics. To obtain a ...
A. Avanzini, and G. Donzella
Department of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy
The mitral valve apparatus is a complex and refined mechanism located between the left atrium and the left ventricle of the heart which can manifest various kinds of pathologies. In order to support identification of potentially critical conditions resulting from some typical cardiosurgery operations, it is important to develop models of the mitral valve that enable prediction of both stress in ...