M. Riou, C. Maedler, S. Erramilli, P. Mohanty
Boston University, Boston, MA, USA
Biosensors based on silicon nanowires are of great interest for ultrasensitive biomolecular recognition of disease specific markers for early stage diagnosis . However, there are limitations on the performance of these nanosensors in solutions at high ionic strength. This is because the electric field induced by the binding of biomolecule is partially screened on length-scales larger than the ...
K. Cluff, L. Saeednia, H. Mehraein , R. Asmatulu
Department of Bioengineering, Wichita State University, Wichita, KS, USA
Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
Polymeric hydrogel is a promising class of drug delivery systems with the controlled release behavior in the body. In-situ forming hydrogels can be injected into the body as a fluid which forms a gel within the body tissue and improve the efficacy of the drugs. Various polymers have been used as in-situ hydrogel formulations. These polymeric formulations can form gels at body temperature while ...
P. Muyshondt, J. Soons, D. de Greef, J. Peacock, J. Dirckx
University of Antwerp, Antwerp, Belgium
The middle ear of birds is a fascinating mechanical system, as it contains only one bony ossicle, compared to three in mammals, yet its auditory performance is not substantially worse. Its design resembles some currently used middle ear prostheses, so the understanding of its working could improve the treatment of some forms of hearing impairment. We have constructed a finite element model of a ...
H. T. D. Grigg, T. H. Hanley, B. J. Gallacher
Newcastle University, Newcastle, Tyne and Wear, UK
This work enunciates the principles of SAW design from a physical perspective, examining the standard engineering modelling assumptions in some detail. An integral form analytical expression based on 2D elastic isotropic theory is validated against a COMSOL Multiphysics® simulation, corresponding to the traditional COM approach. Next, a COMSOL model of the full 3D problem, including anisotropy, ...
Biofluid-Structural Interaction in Abdominal Aortic Aneurysm for Predicting Timeline to Rupture: The Effect of Hypertension and Aorta Wall Material Properties
K. Cluff, H. Mehraein, G. Jayakumar
Bioengineering, Wichita State University, Wichita, KS, USA
Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA
An abdominal aortic aneurysm (AAA) is a bulge formed in the large blood vessels that supply blood to the abdomen, pelvis, and legs. A fluid structure interaction model was developed in a 3D aortic aneurysm model, which was constructed from abdominal CT scan images. Combining medical imaging and computational fluid dynamics (CFD) in a time dependent study allowed the determination of wall ...
Analysis of Heat Transfer in a Complex Three Dimensional Structure Fabricated by Additive Manufacturing
C. Settle, K. Hoshino
Biomedical Engineering Department, University of Connecticut, Storrs, CT, USA
The goal of this study was to create a three dimensionally designed biomedical device with multiple functionalities and analyze its simulated heat transfer. The device would be fabricated through additive manufacturing; specifically electron beam melting (EBM). EBM has a feature size constraint of 1 mm (acceptable for this design) and is only capable of manufacturing titanium alloys ; a ...
O. Yassine, M. Kavaldzhiev, J. Kosel, Q. Li, A. Alfadhel, A. Zaher
Electrical Engineering Division, CEMSE Group, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
Thermally responsive microgel Poly (N-isopropylacrylamide), particles are embedded with iron oxide nanobeads creating magneto-thermally responsive microparticles (MTMs). The magnetic losses in the nanobeads activate the PNIPAM by heating it up to its lower critical solution temperature (LCST), which is approximately 32°C. The COMSOL Multiphysics® software with Heat Transfer Module is used to ...
Conductivity Estimation of Breast Cancer Using COMSOL® Modeling of Microwave Scattering and Frechet Mean Estimate of Covariance
A. Jeremic, E. Khoshrowshahli
Electrical & Computer Engineering, McMaster University, Hamilton, ON, Canada
Biomedical Engineering, McMaster University, Hamilton, ON, Canada
Breast cancer detection is one of the most important problems in health care and it is second most frequent cancer according to WHO. It is recommended that women over fifty or even younger in some cases do a screening test every two years. Besides clinical breast examination, there are number of imaging methods used for this purpose, such as mammography, ultrasound and MRI. Among them, ...
S. D. Evans, J. S. Roth, M. R. Cheetham
University of Leeds, Leeds, UK
Brownian ratchets and electric fields are used for the transport of membrane components. Transport is achieved through the combination of a pattern with free diffusion. We show a good agreement between simulation and experiment, therefore allowing for further optimisation of the ratchets using COMSOL Multiphysics. In addition to the transport device we also introduce the possibility to ...
E. Lacatus, G. C. Alecu, A. Tudor, M. A. Sopronyi
Polytechnic University of Bucharest, Bucharest, Romania
Student-Polytechnic University of Bucharest, Bucharest, Romania
INFLPR -National Institute for Laser Plasma and Radiation Physics, Bucharest, Romania
Vibration and music therapies are non-invasive treatments having effective results although their basics are still disputed. By the application of COMSOL Multiphysics® software for modeling and analysis, some of the nonlinear physical phenomena laying on these applications may be clarified. Acoustic environmental stimuli at different intensities are continuously interacting with our bodies, ...